Description
Product Characteristics:
Aliases: Acidic C4 antibody, Acidic complement C4 antibody, Basic C4 antibody, Basic complement C4 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody, C4, Chido form antibody, C4, Rodgers from antibody, C4A anaphylatoxin antibody, C4A antibody, C4A2 antibody, C4A3 antibody, C4A4 antibody, C4A6 antibody, C4AD antibody, C4B antibody, C4B_2 antibody, C4B1 antibody, C4B12 antibody, C4B2 antibody, C4B3 antibody, C4BD antibody, C4F antibody, C4S antibody, CH antibody, Chido form of C4 antibody, CO4 antibody, CO4A_HUMAN antibody, Complement C4 A antibody, Complement C4 B antibody, Complement C4 gamma chain antibody, complement C4-A antibody, complement C4-B antibody, complement C4-B-like antibody, complement C4B1a antibody, Complement component 4A (Rodgers blood group) antibody, Complement component 4A antibody, complement component 4B (Chido blood group) antibody, complement component 4B (Chido blood group), copy 2 antibody, Complement component 4B (Childo blood group) antibody, Complement component 4B antibody, Complement component 4F antibody, Complement component 4S antibody, CPAMD2 antibody, CPAMD3 antibody, RG antibody, Rodgers form of C4 antibody
Target Information: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]